Efficient synthesis of (5-oxo-6,7-dihydro-4H-[1,2,4]triazolo-[1,5-a]pyrimidin-6-yl)acetanilides based on the recyclization of N-arylitaconimides with 3-amino[1,2,4]triazoles
نویسندگان
چکیده
A convenient method for the synthesis of 2-(2-R-5-oxo-6,7-dihydro-4H-[1,2,4]triazolo-[1,5-a]pyrimidin-6-yl)acetanilides based on regioselective domino reaction N-arylitaconimides with substituted 3-aminotriazoles was proposed. Presumably, pathway includes conjugated aza-addition endo-nucleophilic center triazole to imide, followed by recyclization intermediate triazolo[1,5-a]pyrimidine.
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3-(2’-n-butylbenzofuran-3’-yl)-5-aryl-4, 5-dihydro-1H-pyrazoles (4a-4k) have been synthesized. The synthesized products have been assayed for their antimicrobial activity against Gram+ve, Gram-ve bacteria and fungi. All the synthesized products were assigned with IR, 1HNMR, Mass Spectra, TLC, and elemental analysis. Some of the products showed moderate activi...
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ژورنال
عنوان ژورنال: Russian Chemical Bulletin
سال: 2021
ISSN: ['1573-9171', '1066-5285']
DOI: https://doi.org/10.1007/s11172-021-3118-2